Description

BPC-157, a peptide consisting of 15 amino acids, has been studied in animal models for its potential to promote the healing of tissues such as tendons, joints, nerves, and the gastrointestinal tract.(1,2) It is believed to work through mechanisms like promoting nitric oxide synthesis, stimulating tissue-repair cells, encouraging growth factor production, and reducing inflammation.

In studies of the beneficial effects of BPC-157,a potential therapeutic improvement was found for central nervous disorders. The peptide was shown to counteract brain damage from stroke, improve memory and motor function, and support gene expression in the hippocampus. BPC 157 also alleviated symptoms in models of schizophrenia and catalepsy by influencing the nitric oxide and dopamine systems. Additionally, it promoted healing and functional recovery after spinal cord injury. Overall, BPC 157 appears to offer broad therapeutic benefits, addressing brain damage, neurotransmitter disturbances, and inflammation. (3)

There are also studies that suggest that this peptide promotes healing and functional restoration of completely transected quadriceps muscle in rats. Administered systemically, BPC-157 accelerates muscle healing, improving biomechanical strength, functional recovery, and muscle regeneration over a 72-day period. Muscle fibers reconnect, gaps close, and the muscle’s appearance and function return near normal levels. This suggest that BPC-157 may have therapeutic potential for treating muscle injuries and disorders. (4)

(1)Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and tissue research, 377(2), 153–159. https://doi.org/10.1007/s00441-019-03016-8

(2) Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … & Kolega, Z. (1997). BPC 157’s effect on healing. Journal of Physiology-Paris, 91(3-5), 173-178.

(3)Vukojevic, J., Milavić, M., Perović, D., Ilić, S., Čilić, A. Z., Đuran, N., Štrbe, S., Zoričić, Z., Filipčić, I., Brečić, P., Seiverth, S., & Sikirić, P. (2022). Pentadecapeptide BPC 157 and the central nervous system. Neural regeneration research, 17(3), 482–487. https://doi.org/10.4103/1673-5374.320969

(4) Staresinic, M., Petrovic, I., Novinscak, T., Jukic, I., Pevec, D., Suknaic, S., … & Sikiric, P. (2006). Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157. Journal of orthopaedic research, 24(5), 1109-1117.

Additional information